Detalhe da pesquisa
1.
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.
Annu Rev Microbiol
; 74: 431-454, 2020 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32905757
2.
Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.
Nature
; 576(7786): 315-320, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31776516
3.
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.
PLoS Pathog
; 18(2): e1010278, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35130315
4.
Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials.
J Infect Dis
; 226(11): 2021-2029, 2022 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36082431
5.
Identification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strains.
Antimicrob Agents Chemother
; 59(2): 1110-8, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25487796
6.
Bayesian models trained with HTS data for predicting ß-haematin inhibition and in vitro antimalarial activity.
Bioorg Med Chem
; 23(16): 5210-7, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25573118
7.
N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity.
Bioorg Med Chem
; 23(7): 1530-9, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25725608
8.
Synthesis, ß-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various substituents at C2, C6, and N11.
Bioorg Med Chem
; 22(9): 2629-42, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24721829
9.
hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole.
ACS Med Chem Lett
; 15(4): 463-469, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38628794
10.
Identifying inhibitors of ß-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches.
Sci Rep
; 13(1): 2648, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36788274
11.
Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in Plasmodium falciparum, and Synergize with Clinical Antimalarials.
ACS Infect Dis
; 9(3): 653-667, 2023 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36802523
12.
Drug discovery in Africa tackles zoonotic and related infections.
Sci Transl Med
; 15(718): eadj0035, 2023 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37851825
13.
Antimalarial drug discovery: progress and approaches.
Nat Rev Drug Discov
; 22(10): 807-826, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37652975
14.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Cell Chem Biol
; 29(5): 824-839.e6, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233174
15.
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Sci Rep
; 11(1): 2121, 2021 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483532
16.
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
J Med Chem
; 64(4): 2291-2309, 2021 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33573376
17.
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.
Cell Chem Biol
; 27(7): 806-816.e8, 2020 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32359426
18.
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
Nat Commun
; 9(1): 3314, 2018 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30115924
19.
Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized Plasmodium falciparum NODscidIL2Rγ null Mouse Model of Malaria.
J Med Chem
; 61(9): 4213-4227, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29665687
20.
Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum.
ACS Med Chem Lett
; 8(2): 201-205, 2017 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28197312